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OptiMag® Neuro features magnesium L-threonate (as Magtein®), the only form of magnesium known to cross the blood-brain barrier. Magnesium L-threonate combined with magnesium lysinate glycinate chelate and di-magnesium malate boosts magnesium in the brain.
Dietary intakes of magnesium are consistently below minimum recommended levels, and an insufficiency of magnesium is implicated in a wide range of health concerns, including those that affect the brain. Because many forms of magnesium have low bioavailability, XYMOGEN carefully selected magnesium compounds backed by research and studies to formulate OptiMag Neuro. Built upon the long-term clinical success of OptiMag 125, OptiMag Neuro features a unique combination of OptiMag 125’s highly absorbable, organic Albion minerals—dimagnesium malate and TRAACS® magnesium lysinate glycinate chelate—and Magtein™. Magtein is a groundbreaking organic magnesium compound that was developed by MIT (Massachusetts Institute of Technology) researchers to support “brain power.”
Maintaining extracellular magnesium in the brain helps preserve synaptic density and keeps the synapses working properly. By increasing magnesium concentration in the extracellular fluid, researchers observed permanent enhancement of synaptic plasticity in networks of cultured hippocampal neurons. Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are rich in the hippocampus and play a pivotal role in memory processes. Data from these studies suggest that increasing brain magnesium with Magtein “enhances both short-term synaptic facilitation and long-term potentiation and thereby supports synaptic plasticity and learning and memory functions in rats.”
Magnesium is known to benefit the body in ways that counter stress, promote restful sleep, and support a healthy mood. In rats, magnesium administration attenuated neurologic changes brought on by chronic mild stress. Additionally, by increasing fear memory extinction, Magtein showed promise as a modulator of worry. In human studies, magnesium supplementation partially reversed sleep changes associated with aging and improved objective and subjective measures of sleep. Improving sleep quality and countering the effects of chronic stress positively impact mood—another area that is beneficially influenced by optimal magnesium status.