The Micronized Lipid Matrix tablet system allows pregnenolone to be directly presented to the
systemic circulation via the lymph. The lipid matrix protects the micronized pregnenolone, which are less than 50 microns in size, from the harsh gastric juices, and then allows them to be absorbed via the lymph. By avoiding the hepatic portal vein and the liver ‘first-pass effect’, higher levels of pregnenolone are available, for a longer time period.
Pregnenolone is a naturally occurring metabolite of cholesterol that acts as a precursor to all
adrenal cortical steroids, including progesterone, testosterone, dehydroepiandrosterone, dihydrotestosterone, aldosterone, cortisol, and estradiol. The body produces pregnenolone from cholesterol in the mitochondria through the cytochrome P450 conversion system. The brain requires pregnenolone, producing it and also absorbing more from the blood.
Naturally occurring pregnenolone is found in young people of both sexes at a very high concentration. As with DHEA levels, pregnenolone levels decrease with age. At age 75 one has on average 60% less pregnenolone than one had at 35 years of age (DHEA levels decrease even more rapidly).
Pregnenolone supports the body’s ability to deal with stress, and can potentially enhance the sense of well-being, decrease fatigue, and enhance neuronal connections and memory.
It has been reported to modify sleep EEG by increasing REM sleep, and to increase the time of slow wave sleep with no change in cortisol or growth hormone production. Pregnenolone has been noted to have the most profound effects on those who are most fatigued, supporting their energy, reaction time and decision making. Overall, pregnenolone supports the general
feeling of well being and a normal levels of bodily energy, particularly when dealing with stressful
According to hormone expert Ray Peat, in the body pregnenolone is mostly converted into progesterone and DHEA, and pregnenolone supplementation, along with thyroid support, is a balanced way to increase DHEA.
It is recommended to measure hormone levels prior to starting pregnenolone, and to check periodically while supplementing.