Pantethine is an important metabolite in the production of cellular energy and in lipid metabolism. It appears in the body during the metabolism of pantothenic acid (vitamin B5). Pantethine is the stable disulfide form of an intermediate (pantetheine) in the transformation of pantothenic acid to coenzyme A. Coenzyme A plays a key role in the metabolism of amino acids, carbohydrates and lipids, and is essential for the synthesis of other important substances such as acetylcholine. Whereas pantothenic acid is water soluble and unused pantothenic acid is quickly excreted via the urinary tract, pantethine can stay in the bloodstream for up to 16 hours, maximizing its support of energy and lipid metabolism.
Pantethine supports the health of the cardiovascular and circulatory systems by supporting a healthy balance of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, within normal levels, and may help decrease the cholesterol content of platelet membranes. In addition, pantethine may have antioxidant activity, and may increase platelet membrane fluidity.