TrueBroc® broccoli seed extract is obtained using a patented process to extract glucoraphanin (also known as sulforaphane glucosinolate or “sgs”) from its most concentrated cruciferous source—broccoli seeds. Glucoraphanin is enzymatically converted to the extensively researched isothiocyanate known as sulforaphane (SFN). Research suggests that SFN supports long-lasting antioxidant activity and the production of detoxification enzymes. It also extends support to the immune, nervous, and cardiovascular systems, addressing the maintenance of good health throughout adult life.
Antioxidant and Detoxification Support: Sulforaphane, upon conversion from glucoraphanin, is found to be an effective long-acting indirect antioxidant and significant inducer of phase II detoxification enzymes. Research suggests that SFN strongly induces expression of key enzymes (via the KEAP1/Nrf2/ARE pathway), which in turn supports antioxidant activity, redox cycling, and phase II detoxification. The antioxidant enzymes generated are believed to participate in the recycling and maintenance of vitamins A, C, and E as well.
Support for Cellular Health and Cell-Life Cycles: Glucoraphanin and SFN are believed to play an important role in maintaining healthy gastrointestinal flora; healthy cellular life cycles; immune, eye, and cardiovascular health; and a normal response to inflammation. Sulforaphane’s induction of phase II enzymes, coupled with an inhibitory effect on certain phase I enzymes, is considered to have a protective effect on cells. Research suggests that SFN plays a multidimensional role in maintaining normal cellular life cycles, inhibiting tubulin polymerization, activating checkpoint 2 kinase, and inhibiting histone deacetylase activity. These actions assist in gene regulation, normal cell growth, and cytokine balance.
Research suggests that sulforaphane’s effect on Nrf2 pathways, macrophage activation, and NF-kappa B may support a normal, healthy response to inflammation and promote cardiovascular and eye health. Sulforaphane is also studied for its role in maintaining immune health and a healthy gastrointestinal microflora.