In response to stress, the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis signal to the adrenals to release catecholamines (norepinephrine and epinephrine) and cortisol. Prolonged stress is associated with dysregulation of the HPA axis, which can affect catecholamine and cortisol levels.
L-methionine is a precursor to S-adenosylmethionine (SAMe), which is directly involved in methylation process including catecholamine synthesis.
L-tyrosine is a precursor to catecholamines including dopamine, norepinephrine, and epinephrine.
L-histidine is a precursor to histamine. In the central nervous system, histamine plays an important role in the release of pituitary hormones and wakefulness.
Rhodiola rosea root extract is an adaptogen that has been shown to reduce stress-induced effects.
Green tea leaf extract contains Epigallocatechin gallate (EGCG), a polyphenol that provides antioxidant protection by its ability to scavenge free radicals and metal ions; EGCG has been shown to increase resistance to fatigue.
Active forms of pantothenic acid, niacin, B6, folate, B12, and C are important for the synthesis of adrenal hormones and neurotransmitters.
Adrecor contains amino acids and vitamins important for the synthesis of adrenal hormones and neurotransmitters.
- 5-MTHF and vitamin B12 are important for methylation processes including the synthesis of catecholamines
- Pantothenic acid is the precursor to coenzyme A (CoA), a coenzyme important for the energy production and hormone synthesis.
- Cortisol induces the conversion of norepinephrine to epinephrine.
- Catecholamines play an important role in mood, energy, memory, attention, and cognition
Catecholamines are involved in the central and peripheral stress responses
- The locus coeruleus is the primary source of norepinephrine in the brain and is involved in the initiation of the central stress response.
- Depletion in catecholamines has been associated with fatigue and decreased vigor.