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  • Metagenics SPM Active 60sg Metagenics
  • Metagenics SPM Active 60sg Metagenics
  • Metagenics SPM Active 60sg Metagenics

SPM Active 60sg Metagenics

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SPM Active is designed to help support the body’s natural capacity to respond to physical challenges and resolve the immune response.

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Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.

The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.

The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.

During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.

While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.

Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.


  • Reprogram immune cells by encouraging immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.
  • Help restore balance by returning the body to homeostasis after a physical challenge and supporting overall wellbeing.
  • Support resilience by playing a role in the body's ability to bounce back from environmental challenges. 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.