Your cart is currently empty
5-MTHF is an active, tissue-ready form of folate, an essential B vitamin that supports heart, brain, and blood health. It supports mood, heart health, fetal development, and the nervous system.
5-MTHF, also known as Methylfolate, is the preferred form of folate supplementation because it is the active form of folate used by the body’s tissues.
Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.
Benefits of Thorne’s 5-MTHF:
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.